Pharmacologic Vitreolysis

Molecular biology of pharmacologic vitreolysis.

PURPOSE Pharmacologic vitreolysis is a promising new therapy to improve vitreoretinal surgery and, ultimately, prevent disease by mitigating the contribution of vitreous to retinopathy. The mechanism of action of the agents being developed for pharmacologic vitreolysis remains unclear. The experiments in this thesis test the hypothesis that pharmacologic vitreolysis agents break down vitreous m...

مروری بر روشهای داروئی جداسازی زجاجیه و

  Introduction : The vitreoretinal interface is involved in a wide range of vitreoretinal disorders and separation of the posterior vitreous face from the retinal surface is an essential part of vitrectomy surgeries. A diverse range of enzymatic and non-enzymatic agents are being studied as an adjunct before or during vitrectomy to facilitate the induction of posterior vitreous detachment. Ther...

Novel vitreous modulators for pharmacologic vitreolysis in the treatment of diabetic retinopathy.

Vitreous constitutes about 80% of the volume of the human eye. It is an extended extracellular matrix that is composed of collagen, hyaluronan, and other extracellular matrix molecules, but mostly water. In both health as well as disease, especially diabetic retinopathy (DR), special attention should be drawn to the posterior vitreous cortex and its relation to the retinal surface. The importan...

Floaters and reduced contrast sensitivity after successful pharmacologic vitreolysis with ocriplasmin

Purpose To describe the onset of floaters and reduction in contrast sensitivity (CS) following successful pharmacologic vitreolysis with ocriplasmin for the treatment of vitreo-macular traction (VMT) in a patient with previously normal CS. Observations A 65-year-old woman with a past ocular history of normal visual acuity (VA = 20/26) and contrast sensitivity (1.81% Weber) presents with a 4-m...

[Posterior vitreous detachment and pharmacologic vitreolysis: the new age of enzymatic vitrectomy].

Pharmacologic vitreolysis--premise and promise of the first decade.

Pharmacologic Vitreolysis— Premise and Promise of the First Decade The term pharmacologic vitreolysis first appeared in the world’s literature one decade ago in the pages of the journal Retina.1 The coining of this term formalized a new field and was predicated on a premise and a promise. The premise was that we now understood enough about the molecular organization, structure, and physiology o...